News

Healthcare Hackathon Mainz

At the Healthcare Hackathon at the University Medical Center Mainz, experts from the field of healthcare met with startups, programmers, and industry partners. In interdisciplinary mixed teams, technology-based solutions were developed for practical challenges in hospitals and care. For TRON, Jonas Ibn-Salem participated in the hackathon and worked with experts from IBM, Garmin, BioNTech and
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CIMT 2019 Poster Award

At the annual meeting of the Association for Cancer Immunotherapy (CIMT) in 2019, six scientists received the CIMT Poster Award. Thomas Rösler, a scientist from TRON, won the prize in the category ‘Therapeutic Vaccination’ for his work ‘Modelling immunogenicity with omics data integration’ (Abstract 37). He presented his algorithm TOPAZ, which defines candidates for cancer
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CIMT 2019 Annual Meeting

The Association for Cancer Immunotherapy CIMT’s Annual Meeting brings the world’s top cancer biology and immunotherapy researchers together in the heart of Europe.  The 2019 Annual Meeting will take place May 21-23 at the Rheingoldhalle Congress Center in Mainz.
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CiiM Lecture Series: Individualized Cancer Immunotherapy

Hannover, May 8, 2019 – The Center for Individualised Infection Medicine CiiM lecture series is held at Hannover Medical School. Ugur Sahin will be speaking about Individualized Cancer Immunotherapy on Wednesday, May 8th at 17:00, in Building J01, Lecture Hall N.  CiiM is a joint institution of the Helmholtz Center for Infection Research (HZI) and
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Hohe Auszeichnung für Mainzer Krebsforscher

Professor Ugur Sahin erhält den Deutschen Krebspreis 2019 Mainz, 28. Februar 2019 – Univ.-Prof. Dr. Ugur Sahin hat den Deutschen Krebspreis 2019 erhalten – eine der angesehensten Auszeichnungen in der Krebsmedizin in Deutschland. Prof. Sahin erhält den Preis in der Kategorie Transferforschung für seine wegweisenden Arbeiten zu individualisierten Krebsimmuntherapien, insbesondere für die Entwicklung und klinische
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At the top of the world with personalized cancer immunotherapy

Official foundation ceremony of HI-TRON Mainz Mainz, February 14, 2019 – The new Helmholtz Institute for Translational Oncology (HI-TRON Mainz) is to become one of the world’s leading centers for personalized cancer immunotherapy. This is the ambitious goal of the cooperation partners German Cancer Research Center (DKFZ) and the Research Institute Translational Oncology (TRON gGmbH)
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TRON celebrates young talent

Mainz, January 31, 2019 – TRON celebrates young talent TRON is sponsoring two scholarships in the Deutschlandstipendium 2018/2019 of the Johannes Gutenberg University Mainz, thereby supporting two young medical students as part of this Federal Ministry of Education and Research program. On January 31st, the festive dinner for Deutschlandstipendium sponsors and scholarship holders took place
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Ugur Sahin at 1st German Cancer Research Congress

Mainz, February 5, 2019 – The 1st German Cancer Research Congress (GCRC) is taking place in Heidelberg 4-5 February, showcasing the best cancer research in Germany.   Ugur Sahin will speak in the session on Tumor Immunology and Immunotherapy on Tuesday, February 5th.   For more information on this event, please see the official DKFZ website.
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Harnessing Tumor Mutations for Truly Individualized Cancer Vaccines

Mainz, February 5, 2019 – TRON is thrilled to announce a review published in Annual Review of Medicine authored by Ugur Sahin. In this overview article targeting the medical community, Prof. Sahin defines the cancer mutanome and why this is a valuable source of potential vaccines targets in oncology. The review goes on to describe
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Ugur Sahin presents at Keystone Symposium on Cancer Vaccines

Mainz, January 21, 2019 – The Keystone Symposium on Cancer Vaccines is occurring 20-24 January, 2019, at the Fairmont Hotel in Vancouver, Canada.   Ugur Sahin will speak in the session on Novel Cancer Vaccine Platforms on Wednesday, January 23rd.  The title of his lecture is “RNA-based Vaccines”.   For more information on this event,
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Neoepitope specific T cells can be functionally irrelevant

Mainz, December, 2018 – TRON is proud to have taken part in the research that lead to this publication in OncoImmunology. This publication – in collaboration with scientists from BioNTech, DKFZ, JPT, and the University Medicine Mainz – points to hurdles on our way to highly personalized cancer immunotherapy. The research group investigated neoepitope-specific CD8+
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Actively personalized vaccination trial for newly diagnosed glioblastoma

Mainz, December 20, 2018 – TRON is delighted to announce an article published in Nature.   Working with GAPVAC (Glioma Actively Personalized Vaccine Consortium), TRON participated in developing a highly personalized approach to the treatment of glioblastoma. The consortium publish data on the results of a phase 1 multi-center, multi-national clinical trial, showing favorable safety
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Nanomedicine and macroscale materials in immuno-oncology

Mainz, November 27, 2018 – TRON is delighted to announce an article published in Chemical Society Reviews co-authored by Mustafa Diken. In collaboration with a European team of scientists working on nanomaterials in medicine, Dr. Diken provides an overview of the current state-of-the-art concerning nano- and macroscale materials and their application in immunotherapy. Covering current
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TRON Presented its Expertise in “Life Sciences”

TRON published an advertorial in the November 2018 issue of the Life Sciences magazine published by goingpublic.de. The advert featured TRON’s core competences and highlighted our leading edge research accomplishments. A PDF version of this article is available for download (German only).
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Mustafa Diken gives a lecture at the EMDS conference in Verona

Verona, September 27, 2018 – The Macrophage and Dendritic Cell Society is holding its 32nd annual meeting 27-29 September in beautiful Verona, Italy. This year’s theme is “the crossroad between macrophage and dendritic cells: from immunometabolism to single cell fate.” In this context, TRON’s Mustafa Diken is giving today’s Happy Hour Lecture, entitled “Bringing the
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Djindjic Internship Programme

Mainz, September 2018 – TRON is proudly hosting a scholar from the Zoran Djindjic Program (ZDS). Created in 2003 after the assassination of the first democratically elected Prime Minister of Serbia, and supported by the German federal government, the aim of the program is to provide short internships in German institutions for highly qualified candidates
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TRON Promotes Young Talents

Mainz, September 2018 – TRON is sponsoring two scholarships in the Deutschlandstipendium 2018/2019 of the Johannes Gutenberg University Mainz, thereby supporting two young medical students as part of this Federal Ministry of Education and Research program. Scholarship holders were selected based on proven excellence, exceptional social commitment, and special social or family circumstances.
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NEW TRON PUBLICATION IN EJNMMI RESEARCH

Mainz, September 7, 2018 – TRON is thrilled to announce an article co-authored by Mustafa Diken and Lina Hilscher in the journal EJNMMI Research (European Journal of Nuclear Medicine and Molecular Imaging Research).   In collaboration with Dr. Matthias Miederer’s group in the Department of Nuclear Medicine at the University Medical Center Mainz, TRON scientists
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1st Science Day 2018 at the University Cancer Center Mainz

Mainz, September 6, 2018 – The University Cancer Center at the University Mainz is host to their 1st Science Day 2018 on September 6th 2018. The event features a variety of young investigators and established scientists presenting their research in the fields of cancer immunotherapy, genetic instability, epidemiology, or drug delivery. Our doctoral student Nadja
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New ITN addresses the studies of pathological processes in cardiovascular diseases

Mainz, August 22, 2018 – The Center for Thrombosis and Hemostasis (CTH) at the University Medical Center Mainz is host to a new Innovative Training Network (ITN) „TICARDIO – Thrombo-Inflammation in Cardiovascular Disease“. It will address the studies of pathological processes in cardiovascular diseases. The ITN offers 15 science graduate students the opportunity to develop
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Common goal: More powerful immunotherapies against cancer

Mainz, August 10, 2018 – The new Helmholtz Institute “HI-TRON Mainz” aims to develop effective immunotherapies and identify new biomarkers for cancer treatments. HI-TRON is a collaboration between the German Cancer Research Center (DKFZ) and the research institute TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University Mainz. Cooperation agreements have
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Challenges towards the realization of individualized cancer vaccines

Mainz, August 10, 2018 – TRON is delighted to announce a Comment authored by Özlem Türeci and Ugur Sahin in the journal Nature Biomedical Engineering. “Challenges towards the realization of individualized cancer vaccines” discusses the challenges of optimizing vaccine design, manufacturing and affordability, and identifying the most suitable clinical setting(s).  TRON colleagues Martin Löwer, Barbara
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TRON enters into a research collaboration with Astellas Pharma Inc., Japan

Mainz – TRON (Translational Oncology at the University Medical Center of the Johannes Gutenberg-University Mainz), a non-profit organization and internationally recognized leader in tumor immunology and cancer therapy research, has entered into a research collaboration with Astellas Pharma Inc., a company dedicated to improving the health of people through the provision of innovative and reliable
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OVERCOMING THE INNATE RESISTANCE OF CANCER TO THERAPY

Trento, Italy, June 26, 2018 – Currently, oncologists and cancer scientists face an abiding problem of major proportion, namely the emergence of resistance of certain cancers-some very common- to any therapy during their course. For some of these tumors, such as melanoma and kidney cancer, immune therapy has shown remarkable effects, but only a small
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Krebstherapien maßgeschneidert für jeden Patienten

Mainz, 17. Mai 2018 – Jeder Tumor ist anders. “Krebs entsteht durch individuelle Mutationen”, erklärt Prof. Dr. Ugur Sahin. “Wenn wir uns zum Beispiel den Lungenkrebs verschiedener Patienten anschauen, dann sind diese sehr unterschiedlich. Sie haben im Durchschnitt weniger als fünf Prozent der Mutationen gemeinsam, 95 Prozent sind ganz individuell. Herkömmliche Therapieansätze konzentrieren sich auf
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Biomedical Informatics Symposium

Mainz, June 20, 2018 – Computational Analysis becomes ever more important for the advancement of personalized medicine. Bioinformatics accelerate the patient-centric molecular characterization of diseases and lead to a deeper understanding of the underlying mechanisms thus facilitating the development of novel drugs. Progress in Artificial Intelligence has a strong impact on clinical decision making in
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The Evolution of RNA-based Cancer Vaccines

Ghent, Belgium, May 25, 2018 – VIB conference series hosts the MEDICAL BIOTECHNOLOGY focus meeting May 24-25, 2018, in Ghent Belgium. The conference features talks on new disruptive technologies for early diagnosis and more effective therapeutic intervention in established chronic diseases. Dr. Mustafa Diken will share years of experience in his talk “The evolution of
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CIMT 2018 Annual Meeting

Mainz, May 15-17, 2018 – CIMT 2018 Annual Meeting We are excited about the upcoming Annual Meeting of the Association for Cancer Immunotherapy (CIMT) in our hometown Mainz. Our scientists will be presenting their research in several sessions and look forward to discussing their projects. Thursday, 17 May 2018, Short Talk Session IV Therapeutic Vaccination
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Prof. Ugur Sahin receives prestigious European Research Council (ERC) Advanced Grant for personalized cancer vaccines

Mainz, Germany, April 18, 2018 – Ugur Sahin, Scientific Director at TRON, has been awarded one of the prestigious ERC Advanced Grants 2017 for his project ‘SUMMIT – Stepping Up mRNA Mutanome Immunotherapy’, totaling 2.5 Million Euros over 5 years. The ERC Advanced Grants are awarded to well-established, leading principal investigators to pursue ground-breaking projects. SUMMIT is one
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Authors Comment: HLA and Proteasome Expression Map

Insight into the human HLA expression pattern opens up new ways of improving cancer vaccine development The human leukocyte antigen system (HLA system) is a group of genes that are central to the function of the immune system. These protein complexes can be found either on almost all cells (HLA class I complex) or on
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