tbd
Clinical Translation
Our vision
We support TRON scientists and research teams by providing high-quality human biospecimens and expert clinical pathology services for translational research projects. By integrating reliable Biosampling and sample preparation with pathologist-led tissue characterization, we help researchers to advance scientific discovery while ensuring the highest standards of quality, traceability, rigor, and integrity.
Clinical Pathology & Biosampling
Our activities and competences
-
Biospecimen Collection and Storage
We collect, process, and store high-quality human biospecimens and manage associated data using the caTissue biospecimen inventory management system.
-
Research and Ethics Support
We provide guidance and support in preparing research study protocols for submission to Ethics Committees and support regulatory compliance.
-
Sample Handling and Processing
We coordinate the safe transport, handling, and processing of biospecimens using standardized protocols to ensure sample integrity and suitability for downstream analyses.
-
Research Collaboration
We work closely with both clinical and translational researchers to understand project-specific requirements and provide tailored biospecimen and operational support.
-
Clinical Data Management
We collect, verify, manage, and anonymize associated clinical data while ensuring compliance with ethical, regulatory, and data protection requirements.
-
Quality Assurance
We implement rigorous quality control measures throughout sample collection, processing, storage, and documentation to maintain the highest quality standards.
-
Sample Distribution
Following quality assessment and approval, we release biospecimens with the relevant clinical and technical information to support reliable and reproducible research.
-
Clinical pathology
We provide diagnostic review, tissue characterization, selection of suitable tissue areas and samples, study design, biomarker assessment, and interpretation of histopathological, immunohistochemical, and molecular findings.
Our methods and platforms
Administrative and biosampling support
Cooperation establishment, ethics committee (EC) applications, sample procurement, sample management and storage.
Research support
Retrospective cohort assembly, biospecimen provision, research collaboration.
Fresh tissue processing
Preparation of FFPE, fresh frozen viable & fresh frozen non-viable samples, RNA isolation, and quality control (QC).
FFPE processing
FFPE block sectioning, H&E staining, curl preparation for molecular analysis, macrodissection, RNA isolation, and QC.
Whole blood processing
PBMC isolation from different blood collection tubes for both vital and nonvital storage, plasma collection, ctDNA plasma preparation.
Pleural effusion processing
Cell isolation and supernatant collection from pleural effusion samples.
Synovial fluid processing
Isolation of synovial fluid to prepare it for cfDNA isolation.
Tissue interstial fluid preparations
Upcoming: Generation of tissue interstial fluid preparations for metabolite tracing
