TRON Seminar in Translational Oncology

Mainz, June 09 2016 “Abrogation of the immunosuppressive tumor-microenvironment in Hepatocellular Carcinoma by targeting Treg and co-inhibitory pathways”, Dr. Jaap Kwekkeboom & Dr. Dave Sprengers from the Laboratory of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam are visiting TRON.

5 PM, Lecture Hall Building 708, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany

Jaap Kwekkeboom studied Biomedical Sciences at the University of Utrecht. Dr. Kwekkeboom did a PhD-study on regulation of bile acid synthesis at the Gaubius Institute of the Netherlands Organization for Applied Research (TNO), and received his doctorate at the University of Leiden in 1990. He worked as a postdoctoral fellow at the Academic Medical Centre of Amsterdam on mechanisms of B-cell activation and development of technology to produce human monoclonal antibodies, and thereafter at the Sanquin Research Institute (Amsterdam) on development of technology for processing peripheral hematopoietic stem cell transplants. In 1997 he was appointed as a senior postdoctoral fellow at Erasmus MC (Rotterdam) to initiate translational research on liver transplantation and HBV-infection. In 2004 he became a staff member at the Laboratory of Gastroenterology and Hepatology, Erasmus MC, where he continued his research line on liver transplant immunology. Currently, his research team is mainly focused on developing immunotherapeutic approaches for liver cancer.

Dr. Kwekkeboom (co-)authored more than hundred papers in peer-reviewed international journals. He served as Board Member of the Foundation of Liver and Gastrointestinal Research (SLO) and of the Netherlands Society for Hepatology, and as Deputy Head of the Laboratory of Gastroenterology and Hepatology of Erasmus MC. Currently, he is a Core Teacher of the Erasmus MC Research Master ‘Infection and Immunity’, Member of Erasmus MC Research Master Examination Board, and Associate editor of the American Journal of Transplantation.

More information about his research interests and recent publications can be found at:


Dr. Dave Sprengers studied medicine at the University of Nijmegen (cum laude) and received his doctorate in 2006 at the Erasmus University in Rotterdam with a dissertation on immunomodulation in patients with chronic hepatitis B virus infection. After a postdoctoral internship at Harvard University in Boston where he deepened in immunopathology of liver disease, he completed his training as a gastroenterologist at the Erasmus Medical Center University of Rotterdam in late 2011. Dr. Sprengers then worked for nearly two years as a gastroenterologist at the Academic Medical Center in Amsterdam, after which he further developed his expertise in the field of hepatology at the Erasmus Medical Center from the end of 2013. His clinical and research activities are focussed on the diagnosis and treatment of liver disease with a special interest in the immunology of chronic liver disease and liver cancer.

More information about his research interests and key publications can be found at: