Archive | Technologies

Clinical Immuno-Monitoring

Monitoring the quality and quantity of cellular immune responses in clinical immunotherapy trials aids in evaluating the efficacy of treatment. The nature of the cellular immune response generated could impact the further development of immunotherapeutics, also known as immunoguiding. High-parameter flow cytometry offers a tool addressing multiple markers on samples of different origin (e.g. blood,

Immune assays & imaging

Investigating immunologic mechanisms is a fundamental part of TRON’s translational research. In particular, the efficacy of vaccines and combinatorial therapies to generate, boost and reinvigorate the cellular response against cancers is our focus.  Three specialist teams contribute to this work, both on internal projects and in support of other unit projects. The Vaccines and Cellular

Serodiscovery

The use of (auto)antibodies as markers is one of the most promising prognostic and diagnostic approaches to classifying disease, and is minimally invasive. (Auto)antibodies are excellent biomarkers because they are robust, naturally amplified by the immune system, immunologically memorized and readily and detectable early on. TRON’s Serodiscovery team employs state-of-the-art technologies to identify disease-related (auto)antibody

DNA & RNA vectors

Recombinant nucleic acids – DNA or RNA – and their manipulation and manufacturing are the starting point of many research and development projects. DNA or RNA largely serve to express foreign genes in cells or organisms, either permanently or temporarily. This function of nucleic acids is thereby referred to as vectors, shuttling genes into cells. 

Bioinformatics

Applied Bioinformatics is one of the key scientific disciplines of the 21st century. State-of-the-art bioinformatics approaches are proving indispensable in the development of innovative therapies, which focus on the disease-specific molecular changes in each individual patient.  TRON’s Bioinformatics department comprises a multidisciplinary team of bioinformaticians, biotechnologists, mathematicians, physicists and scientists from other related fields. The

Sequencing & Genomics

Every cell in the human body contains that person’s entire genomic information encoded in the DNA. This also applies to tumor cells, in which external influences can drive the occurrence of small or large variations in the genome. Identifying these unique changes in each patient may help determine the underlying cause of disease and support

Preclinical Models

We have a broad expertise in in vivo antibody treatments (therapeutic antibodies or depletion of specific cell populations for mode of action analysis), combination therapy (checkpoint inhibitors, chemotherapy, local radiotherapy via an Orthovoltage X-Ray device) and the use of specific transgenic models for diverse biological questions. In addition, we apply various immunological methods such as