Archive | spotlight-2017

Novel RNA-based therapy for treatment of autoimmune diseases

Loss of immunological self-tolerance followed by attack of self-reactive T cells to target organs plays a major role in the formation of autoimmune diseases such as multiple sclerosis (MS). In a very recent study published in Science, our researchers (in collaboration with Johannes Gutenberg University Medical Center and BioNTech) employed a non-inflammatory RNA vaccine that

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PhD Student Isabell Keil wins poster prize at CLINAM 2020

TRON is thrilled that PhD candidate Isabell Keil has won a prize for her poster at CLINAM 12/2020 (European Foundation for Clinical Nanomedicine’s 12th Annual Meeting)! Isa’s work, featured in the conference’s Basic Nanomedicine category, is to develop nanoparticle‐based mRNA carrier systems for transient immunomodulation of immune cells. Isa’s poster, along with all poster presentations,

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International initiative TESLA identifies parameters for cancer vaccine or cell therapy advancement

Published in Cell: TRON is part of a 36-member alliance led by the Parker Institute and Cancer Research Institute identifying parameters for better vaccine design in the fight against cancer. As part of TESLA (Tumor Neoantigen Selection Alliance), TRON performed advanced computational analysis on samples from melanoma and non-small cell lung cancer to identify characteristics

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Multi-omics characterization of the 4T1 murine mammary gland tumor model

The murine mammary carcinoma cell line 4T1 is a widely used syngeneic tumor model for human breast cancer and specifically triple-negative breast cancer (TNBC). Profiling tumor models is important to translate pre-clinical findings appropriately. The authors aimed to complement the evaluation of 4T1 as adequate breast cancer or even TNBC model. Analysis of the whole-exome

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TRON wears white for A Future #Immune2Cancer

TRON is proud to join the Cancer Research Institute this June 12 in bringing global awareness about the life-saving potential of cancer immunotherapy. By wearing white together, we are driving the future of immune-based science and medicine for cancer treatments, and ultimately, cures.  Learn more about TRON’s mission and work at www.tron-mainz.de.

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Dr. Luisa Bresadola awarded BMS Young Scientist prize

We are delighted to announce that TRON scientist Dr. Luisa Bresadola has won the Bristol-Myers-Squibb Young Scientist award in the field of immune-oncology! Luisa’s work comprises analysis of head and neck squamous cell carcinoma next-generation sequencing data, generated by TRON in collaboration with the University of Birmingham, to determine tumor evoluation in this cancer entity.

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