Archive | Publications

2020

Becker S, Fink A, Podlech J, Giese I, Schmiedeke JK, Bukur T, Reddehase MJ, Lemmermann NA. (2020) Positive Role of the MHC Class-I Antigen Presentation Regulator m04/gp34 of Murine Cytomegalovirus in Antiviral Protection by CD8 T Cells.  Front. Cell. Infect. Microbiol. 26 August 2020. DOI Show abstractMurine cytomegalovirus (mCMV) codes for MHC class-I trafficking modulators

2019

Beissert T, Perkovic M, Vogel A, Erbar S, Walzer KC, Hempel T, Brill S, Haefner E, Becker R, Türeci Ö, Sahin U. (2019) A trans-amplifying RNA vaccine strategy for induction of potent protective immunity. Mol Ther. pii: S1525-0016(19)30412-5. DOI; PMID Show abstract Here we present a potent RNA vaccine approach based on a novel bipartite

2018

Vormehr M, Reinhard K, Blatnik R, Josef K, Beck JD, Salomon N, Suchan M, Selmi A, Vascotto F, Zerweck J, Wenschuh H, Diken M, Kreiter S, Türeci Ö, Riemer AB, Sahin U. (2018) A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo. Oncoimmunology. DOI; PMID Show abstract  Cancer-associated mutations,

2010

Kettner C, Field D, Sansone S, Taylor C, Aerts J, Binns N, Blake A, Britten CM, Marco A de, Fostel J, Gaudet P, González-Beltrán A, Hardy N, Hellemans J, Hermjakob H, Juty N, Leebens-Mack J, Maguire E, Neumann S, Orchard S, Parkinson H, Piel W, Ranganathan S, Rocca-Serra P, Santarsiero A, Shotton D, Sterk P,

2011

Fox BA, Schendel DJ, Butterfield LH, Aamdal S, Allison JP, Ascierto P, Atkins MB, Bartunkova J, Bergmann L, Berinstein N, Bonorino CC, Borden E, Bramson JL, Britten CM, Cao X, Carson WE, Chang AE, Characiejus D, Choudhury AR, Coukos G, Gruijl T de, Dillman RO, Dolstra H, Dranoff G, Durrant LG, Finke JH, Galon J,

2012

Boegel S, Löwer M, Schäfer M, Bukur T, Graaf J de, Boisguérin V, Türeci O, Diken M, Castle JC, Sahin U: HLA typing from RNA-Seq sequence reads. Genome medicine 2012, 4:102. DOI; PubMed Galon J, Pagès F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F,

2013

Wagner M, Koslowski M, Paret C, Schmidt M, Türeci O, Sahin U: NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells. BMC cancer 2013, 13:570. DOI; PubMed Kloke B, Rae R, Mahr A, Burkhardt UE, Kvistborg P, Britten CM: Toward the next waves of cancer immunotherapy: 11th

2014

Kloke B, Mahr A, Jabulowsky RA, Kutscher S, Rae R, Britten CM: Cancer immunotherapy achieves breakthrough status: 12th annual meeting of the association for cancer immunotherapy (CIMT), Mainz, Germany, May 6-8, 2014. Cancer immunology, immunotherapy: CII 2015, 64:923-930. DOI; PubMed Diken M, Boegel S, Grunwitz C, Kranz LM, Reuter K, van de Roemer, Niels, Vascotto F,

2015

Vormehr M, Diken M, Boegel S, Kreiter S, Türeci Ö, Sahin U: Mutanome directed cancer immunotherapy. Current opinion in immunology 2015, 39:14-22. DOI; PubMed Show abstract Somatic mutations are important drivers of cancer development. Accumulating evidence suggests that a significant subset of mutations result in neo-epitopes recognized by autologous T cells and thus may constitute

2016

Strenkowska M, Grzela R, Majewski M, Wnek K, Kowalska J, Lukaszewicz M, Zuberek J, Darzynkiewicz E, Kuhn AN, Sahin U, Jemielity J: Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential. Nucleic Acids Res. 2016 Nov 16; 44(20):9578-9590 Epub 2016 Oct 7. DOI; PubMed Show abstractAlong with a growing

2017

Vogel AB, Lambert L, Kinnear E, Busse D, Erbar S, Reuter KC, Wicke L, Perkovic M, Beissert T, Haas H, Reece ST, Sahin U, Tregoning JS: Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses. Mol Ther. 2017 Dec 5. pii: S1525-0016(17)30594-4. DOI; PMID Show abstractNew vaccine platforms are needed