Author Archive | karen

Mainz, September 27, 2019 – TRON scientists publish in Molecular Therapy TRON has published an article on a novel RNA-based vector for antigen delivery in Molecular Therapy. Among the exciting results, the authors show that trans-amplifying RNA as a vaccine vector induces protective immune responses against influenza challenge in mice, at a 400x lower dose

Mainz, July 19, 2019 – TRON scientists publish in Oncoimmunology TRON has published an article on the immunomodulatory effects of the TLR7 agonist SC1 in Oncoimmunology.  Among the exciting results, the authors show that SC1 administration leads to inhibition of tumor growth and prolonged survival, and that this effect is dependent on CD8+ T cells. 

Mainz, December 6, 2018 – TRON scientists are co-authors in a Nature Communications article In collaboration with scientists from Italy and Germany, TRON has co-authored an article on the induction of immunosuppressive functions in monocytes by c-FLIP, published in Nature Communications.  The data show that modulation of c-FLIP in monocytes may offer a path to

Mainz, September 11, 2018 – TRON is thrilled to announce a review co-authored by Ugur Sahin in the journal Nature Reviews Drug Discovery.   This article gives an over view of nascent RNA immunotherapeutics, including RNA vaccines encoding cancer neoantigens, mRNAs encoding immunomodulatory factors, viral RNA analogues, interference RNAs and protein-binding RNA aptamers. These approaches

Mainz, May 3, 2018 – The University Medical Center Frankfurt at Goethe University is hosting a seminar in the German Society for Immunology’s Translational Immunology Seminar Series.  TRON’s Mustafa Diken will give a lecture titled “mRNA as a versatile platform for cancer vaccines”  today at 3:00 p.m. in lecture hall B15 of Building 32 (entrance