Mainz, September 27, 2019 – TRON scientists publish in Molecular Therapy TRON has published an article on a novel RNA-based vector for antigen delivery in Molecular Therapy. Among the exciting results, the authors show that trans-amplifying RNA as a vaccine vector induces protective immune responses against influenza challenge in mice, at a 400x lower dose
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Mainz, July 19, 2019 – TRON scientists publish in Oncoimmunology TRON has published an article on the immunomodulatory effects of the TLR7 agonist SC1 in Oncoimmunology. Among the exciting results, the authors show that SC1 administration leads to inhibition of tumor growth and prolonged survival, and that this effect is dependent on CD8+ T cells.
Mainz, February 5, 2019 – The 1st German Cancer Research Congress (GCRC) is taking place in Heidelberg 4-5 February, showcasing the best cancer research in Germany. Ugur Sahin will speak in the session on Tumor Immunology and Immunotherapy on Tuesday, February 5th. For more information on this event, please see the official DKFZ website.
Mainz, January 21, 2019 – The Keystone Symposium on Cancer Vaccines is occurring 20-24 January, 2019, at the Fairmont Hotel in Vancouver, Canada. Ugur Sahin will speak in the session on Novel Cancer Vaccine Platforms on Wednesday, January 23rd. The title of his lecture is “RNA-based Vaccines”. For more information on this event,
Mainz, December 20, 2018 – TRON is delighted to announce an article published in Nature. Working with GAPVAC (Glioma Actively Personalized Vaccine Consortium), TRON participated in developing a highly personalized approach to the treatment of glioblastoma. The consortium publish data on the results of a phase 1 multi-center, multi-national clinical trial, showing favorable safety
Mainz, December 6, 2018 – TRON scientists are co-authors in a Nature Communications article In collaboration with scientists from Italy and Germany, TRON has co-authored an article on the induction of immunosuppressive functions in monocytes by c-FLIP, published in Nature Communications. The data show that modulation of c-FLIP in monocytes may offer a path to
Mainz, September 11, 2018 – TRON is thrilled to announce a review co-authored by Ugur Sahin in the journal Nature Reviews Drug Discovery. This article gives an over view of nascent RNA immunotherapeutics, including RNA vaccines encoding cancer neoantigens, mRNAs encoding immunomodulatory factors, viral RNA analogues, interference RNAs and protein-binding RNA aptamers. These approaches
Mainz, September 7, 2018 – TRON is thrilled to announce an article co-authored by Mustafa Diken and Lina Hilscher in the journal EJNMMI Research (European Journal of Nuclear Medicine and Molecular Imaging Research). In collaboration with Dr. Matthias Miederer’s group in the Department of Nuclear Medicine at the University Medical Center Mainz, TRON scientists
Mainz, May 3, 2018 – The University Medical Center Frankfurt at Goethe University is hosting a seminar in the German Society for Immunology’s Translational Immunology Seminar Series. TRON’s Mustafa Diken will give a lecture titled “mRNA as a versatile platform for cancer vaccines” today at 3:00 p.m. in lecture hall B15 of Building 32 (entrance
Mainz, Germany, April 18, 2018 – Ugur Sahin, Scientific Director at TRON, has been awarded one of the prestigious ERC Advanced Grants 2017 for his project ‘SUMMIT – Stepping Up mRNA Mutanome Immunotherapy’, totaling 2.5 Million Euros over 5 years. The ERC Advanced Grants are awarded to well-established, leading principal investigators to pursue ground-breaking projects. SUMMIT is one
Mainz, March 23, 2018 – TRON is delighted to announce a review authored by Ugur Sahin and Özlem Türeci in the journal Science. “Personalized vaccines for cancer immunotherapy” outlines the genetic basis for why almost every cancer is unique, and how with innovations in mutation mapping, target validation and vaccine production, it is possible to
Mainz, March 16, 2018 – The Dutch Society for Immunology (NVVI) is hosting the 4th Chemical Immunology Conference today in Amsterdam. The meeting aims to cover the broad diversity of chemical immunology and some of the most exciting areas of research to have emerged. TRON’s Mustafa Diken kicks off the day with his plenary, “mRNA