Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA

In this recent study published in European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI), researchers from TRON, JGU Medical Center and BioNTech employed an in vitro transcribed mRNA encoding for sodium iodide symporter (NIS) to efficiently visualize and quantify the biodistribution of NIS RNA-lipoplex nanoparticles targeted to spleen or lung. Tissues expressing the RNA-encoded NIS were rapidly and accurately identified via in vivo small animal PET/MRI upon radioactive Iodine-124 administration providing a novel powerful tool for monitoring the biodistribution of RNA-loaded nanoparticles.

Read more in the original publication: https://doi.org/10.1186/s13550-021-00753-2