A liposomal RNA vaccine augments the antitumor activity of local radiotherapy in mice

TRON is delighted to announce the publication of a scientific article in OncoImmunology.

In this article, TRON authors Nadja Salomon et al. investigated combination therapy in CT26 tumors. CT26 rejection using local radiotherapy (LRT) is augmented by a lipoplex-formulated RNA vaccine that encodes CD4+ T cell-recognized neoantigens. CD4 neoantigen vaccine/LRT treatment followed by anti-CTLA-4 antibody therapy further enhanced the efficacy with complete remission of gp70-negative CT26 tumors.

Read more about this research in the original article.

 

Image created by Nadja Salomon.

 

This work was supported by the Deutsche Forschungsgemeinschaft SFB1292/TP17