TRON Seminar in Translational Oncology: Prof. A. Steinkasserer

April 11, 2013

5 PM in Mainz, Germany

TRON – Building 708 at University Medical Center Mainz

Langenbeckstr. 1

55131 Mainz

Prof. Dr. Alexander Steinkasserer

Head of Dept. of Immune Modulation at the Dept. of Dermatology, Erlangen, Germany

“Induction of regulatory T cells by soluble CD83 – Modulation of the immune system in autoimmunity and transplantation”

Prof. Steinkasserer leads the Department for Immune Modulation at Universitätsklinikum Erlangen. The main focus of Steinkasserer’s current research efforts are concentrated around Dendritic Cell (DC) biology. DC are the most potent antigen presenting cells. Once activated by DC’s, T-cells can complete the immune response by interacting with other cells and targets for lysis. Therefore, DC’s represent a very interesting cell type for gene therapy and vaccination strategies against tumors and viral infections. In order to become potent antigen presenting cells DC have to mature and during this process a whole variety of different gene transcripts are induced. The elucidation of the role and regulation of these transcripts is also a major focus of the research efforts of Steinkasserer’s team in Erlangen. Furthermore, the interaction between DC and viruses (esp. HIV-1 and HSV-1) represents another major field of interest to Steinkasserer’s group.