March 7, 2013
5 PM in Mainz, Germany
TRON – Building 708 at University Medical Center Mainz
Prof. Philipp Beckhove
DKFZ, Division of Translational Immunology, Heidelberg, Germany
“Local irradiation and the role of macrophages for tumor immune rejection”
Dr. Beckhove is the Head of the Translational Immunology Division at the German Cancer Research Institute (DKFZ) in Heidelberg. He studied medicine at the Universities of Hamburg and Heidelberg, and completed his residency in Internal Medicine (Hematology/Oncology) at the University Medical Center, Heidelberg. Dr. Beckhove then became head of the DKFZ Research Group “Translational Immunology” and in 2008 followed a call as Associate Professor for Immunotherapy at the Comprehensive Cancer Center, Northwestern University, Chicago Ill., U.S.A.
Dr. Beckhove is interested in the regulation and clinical impact of immune responses against human cancer, T-cell based cancer immunotherapy, immune modulatory ligands on tumor cells and regulatory T cells, and is working to describe formative and regulative mechanisms of T-cell tumor responses. His group was the first to demonstrate that the majority of tumor patients retain tumor-specific memory cells in their spinal marrow. These findings have led to a new interpretation of the protective mechanisms of tumor immunotherapies. In addition, Dr. Beckhove’s group has identified target antigens for tumor vaccinations and antibody-based immunotherapies, while demonstrating the need for improved migration of tumorlytical T cells in human tumors.