Visualizing Gastric Cancer Through In Vivo Endomicroscopy

Mainz, July 12 – TRON and the University Medical Center of the Johannes Gutenberg University Mainz collaborated on a novel visualization of gastric cancer by using monoclonal antibodies targeting EGFR1 as molecular probes for in vivo molecular confocal laser endomicroscopy (mCLE). The study published in the journal Gastrointestinal Endoscopy used non-invasive in vivo biofluorescence imaging technology at the TRON In Vivo Imaging core facility to confirm the results obtained from mCLE. The scientists expect mCLE to help diagnose and characterize gastric cancer during ongoing gastroscopy and to assist in the prediction of response to therapy.

Michael S. Hoetker, Ralf Kiesslich, Mustafa Diken, Markus Moehler, Peter R. Galle, Yanqing Li, Martin Goetz,. Molecular in vivo imaging of gastric cancer in a human-murine xenograft model: targeting epidermal growth factor receptor. Gastrointestinal Endoscopy. July 7, 2012.