News

Neoepitope specific T cells can be functionally irrelevant

Mainz, December, 2018 – TRON is proud to have taken part in the research that lead to this publication in OncoImmunology. This publication – in collaboration with scientists from BioNTech, DKFZ, JPT, and the University Medicine Mainz – points to hurdles on our way to highly personalized cancer immunotherapy. The research group investigated neoepitope-specific CD8+
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Actively personalized vaccination trial for newly diagnosed glioblastoma

Mainz, December 20, 2018 – TRON is delighted to announce an article published in Nature.   Working with GAPVAC (Glioma Actively Personalized Vaccine Consortium), TRON participated in developing a highly personalized approach to the treatment of glioblastoma. The consortium publish data on the results of a phase 1 multi-center, multi-national clinical trial, showing favorable safety
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Nanomedicine and macroscale materials in immuno-oncology

Mainz, November 27, 2018 – TRON is delighted to announce an article published in Chemical Society Reviews co-authored by Mustafa Diken. In collaboration with a European team of scientists working on nanomaterials in medicine, Dr. Diken provides an overview of the current state-of-the-art concerning nano- and macroscale materials and their application in immunotherapy. Covering current
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TRON Presented its Expertise in “Life Sciences”

TRON published an advertorial in the November 2018 issue of the Life Sciences magazine published by goingpublic.de. The advert featured TRON’s core competences and highlighted our leading edge research accomplishments. A PDF version of this article is available for download (German only).
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Mustafa Diken gives a lecture at the EMDS conference in Verona

Verona, September 27, 2018 – The Macrophage and Dendritic Cell Society is holding its 32nd annual meeting 27-29 September in beautiful Verona, Italy. This year’s theme is “the crossroad between macrophage and dendritic cells: from immunometabolism to single cell fate.” In this context, TRON’s Mustafa Diken is giving today’s Happy Hour Lecture, entitled “Bringing the
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Djindjic Internship Programme

Mainz, September 2018 – TRON is proudly hosting a scholar from the Zoran Djindjic Program (ZDS). Created in 2003 after the assassination of the first democratically elected Prime Minister of Serbia, and supported by the German federal government, the aim of the program is to provide short internships in German institutions for highly qualified candidates
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TRON Promotes Young Talents

Mainz, September 2018 – TRON is sponsoring two scholarships in the Deutschlandstipendium 2018/2019 of the Johannes Gutenberg University Mainz, thereby supporting two young medical students as part of this Federal Ministry of Education and Research program. Scholarship holders were selected based on proven excellence, exceptional social commitment, and special social or family circumstances.
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NEW TRON PUBLICATION IN EJNMMI RESEARCH

Mainz, September 7, 2018 – TRON is thrilled to announce an article co-authored by Mustafa Diken and Lina Hilscher in the journal EJNMMI Research (European Journal of Nuclear Medicine and Molecular Imaging Research).   In collaboration with Dr. Matthias Miederer’s group in the Department of Nuclear Medicine at the University Medical Center Mainz, TRON scientists
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1st Science Day 2018 at the University Cancer Center Mainz

Mainz, September 6, 2018 – The University Cancer Center at the University Mainz is host to their 1st Science Day 2018 on September 6th 2018. The event features a variety of young investigators and established scientists presenting their research in the fields of cancer immunotherapy, genetic instability, epidemiology, or drug delivery. Our doctoral student Nadja
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New ITN addresses the studies of pathological processes in cardiovascular diseases

Mainz, August 22, 2018 – The Center for Thrombosis and Hemostasis (CTH) at the University Medical Center Mainz is host to a new Innovative Training Network (ITN) „TICARDIO – Thrombo-Inflammation in Cardiovascular Disease“. It will address the studies of pathological processes in cardiovascular diseases. The ITN offers 15 science graduate students the opportunity to develop
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Common goal: More powerful immunotherapies against cancer

Mainz, August 10, 2018 – The new Helmholtz Institute “HI-TRON Mainz” aims to develop effective immunotherapies and identify new biomarkers for cancer treatments. HI-TRON is a collaboration between the German Cancer Research Center (DKFZ) and the research institute TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University Mainz. Cooperation agreements have
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Challenges towards the realization of individualized cancer vaccines

Mainz, August 10, 2018 – TRON is delighted to announce a Comment authored by Özlem Türeci and Ugur Sahin in the journal Nature Biomedical Engineering. “Challenges towards the realization of individualized cancer vaccines” discusses the challenges of optimizing vaccine design, manufacturing and affordability, and identifying the most suitable clinical setting(s).  TRON colleagues Martin Löwer, Barbara
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TRON enters into a research collaboration with Astellas Pharma Inc., Japan

Mainz – TRON (Translational Oncology at the University Medical Center of the Johannes Gutenberg-University Mainz), a non-profit organization and internationally recognized leader in tumor immunology and cancer therapy research, has entered into a research collaboration with Astellas Pharma Inc., a company dedicated to improving the health of people through the provision of innovative and reliable
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OVERCOMING THE INNATE RESISTANCE OF CANCER TO THERAPY

Trento, Italy, June 26, 2018 – Currently, oncologists and cancer scientists face an abiding problem of major proportion, namely the emergence of resistance of certain cancers-some very common- to any therapy during their course. For some of these tumors, such as melanoma and kidney cancer, immune therapy has shown remarkable effects, but only a small
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Krebstherapien maßgeschneidert für jeden Patienten

Mainz, 17. Mai 2018 – Jeder Tumor ist anders. “Krebs entsteht durch individuelle Mutationen”, erklärt Prof. Dr. Ugur Sahin. “Wenn wir uns zum Beispiel den Lungenkrebs verschiedener Patienten anschauen, dann sind diese sehr unterschiedlich. Sie haben im Durchschnitt weniger als fünf Prozent der Mutationen gemeinsam, 95 Prozent sind ganz individuell. Herkömmliche Therapieansätze konzentrieren sich auf
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Biomedical Informatics Symposium

Mainz, June 20, 2018 – Computational Analysis becomes ever more important for the advancement of personalized medicine. Bioinformatics accelerate the patient-centric molecular characterization of diseases and lead to a deeper understanding of the underlying mechanisms thus facilitating the development of novel drugs. Progress in Artificial Intelligence has a strong impact on clinical decision making in
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The Evolution of RNA-based Cancer Vaccines

Ghent, Belgium, May 25, 2018 – VIB conference series hosts the MEDICAL BIOTECHNOLOGY focus meeting May 24-25, 2018, in Ghent Belgium. The conference features talks on new disruptive technologies for early diagnosis and more effective therapeutic intervention in established chronic diseases. Dr. Mustafa Diken will share years of experience in his talk “The evolution of
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CIMT 2018 Annual Meeting

Mainz, May 15-17, 2018 – CIMT 2018 Annual Meeting We are excited about the upcoming Annual Meeting of the Association for Cancer Immunotherapy (CIMT) in our hometown Mainz. Our scientists will be presenting their research in several sessions and look forward to discussing their projects. Thursday, 17 May 2018, Short Talk Session IV Therapeutic Vaccination
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Prof. Ugur Sahin receives prestigious European Research Council (ERC) Advanced Grant for personalized cancer vaccines

Mainz, Germany, April 18, 2018 – Ugur Sahin, Scientific Director at TRON, has been awarded one of the prestigious ERC Advanced Grants 2017 for his project ‘SUMMIT – Stepping Up mRNA Mutanome Immunotherapy’, totaling 2.5 Million Euros over 5 years. The ERC Advanced Grants are awarded to well-established, leading principal investigators to pursue ground-breaking projects. SUMMIT is one
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Authors Comment: HLA and Proteasome Expression Map

Insight into the human HLA expression pattern opens up new ways of improving cancer vaccine development The human leukocyte antigen system (HLA system) is a group of genes that are central to the function of the immune system. These protein complexes can be found either on almost all cells (HLA class I complex) or on
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Ugur Sahin and Özlem Türeci publish a review in Science’s Cancer Immunotherapy special issue

Mainz, March 23, 2018 – TRON is delighted to announce a review authored by Ugur Sahin and Özlem Türeci in the journal Science. “Personalized vaccines for cancer immunotherapy” outlines the genetic basis for why almost every cancer is unique, and how with innovations in mutation mapping, target validation and vaccine production, it is possible to
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TRON Seminars in Translational Oncology: Prof. Dietmar Zehn

Mainz, March 2018 – On March 15th, Prof. Dietmar Zehn from the Technical University of Munich, School of Life Sciences Weihenstephan, will be visiting Mainz in the context of our Seminars in Translational Oncology series (SITO). You are cordially invited to his talk at 5 pm in building 708 of the University Medicine Mainz. The
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Ugur Sahin at Keystone Symposium “Antibodies as Drugs”

Mainz, February 16, 2018 – The Keystone Symposium on Antibodies as Drugs: Translating Molecules into Treatments, will take place February 25th – March 1st, 2018 at the Whistler Conference Centre in Whistler, Canada. Ugur Sahin will speak in the session on Novel Ways to Deliver Antibody Therapy on Thursday, March 1.  The title of his lecture
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Three-year research grant to develop new treatment approaches for neuroendocrine tumors

We are pleased to announce a three-year grant from the Falconwood Foundation, New York, USA, totalling 3 Million Euros. The grant supports the launch of a new research project to identify biomarkers specific for neuroendocrine tumors (NETs) that are crucial for the development of new, personalized immunotherapies to treat NET patients. Further details are announced
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TRON shortlisted for Cancer Research UK’s Grand Challenge Award

TRON has been shortlisted for Cancer Research UK’s Grand  Challenge Award as part of team BLUEPRINT   TRON is part of a multi-disciplinary team of scientists that has been shortlisted to the final stages of Cancer Research UK’s Grand Challenge*. The team is led by Dr. Lindy Durrant from the University of Nottingham and includes
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Ugur Sahin at the Keystone Symposium on Lymphocytes and their Role in Cancer

Mainz, January 23, 2018 – The Keystone Symposium on Lymphocytes and their Role in Cancer will take place February 11th-15th 2018 at the Keystone Resort in Keystone, Colorado.  This is a joint event with Emerging Cellular Therapies: T Cells and Beyond. Ugur Sahin will chair the session on Cellular Therapies in Blood Malignancies,  and give a
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Authors’ comments on article in Human Gene Therapy

The concept of delivering genetic material to defective cells to treat diseases or to vaccinate healthy people against infections has been around for quite some time. Nevertheless, key challenges remain, such as efficient delivery of the material as well as duration of gene expression.
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TRON is involved in two projects of a new Collaborative Research Center

In the course of evolution, the immune system has developed sophisticated mechanisms to identify and eliminate invading pathogens and degenerate cells, thereby preventing infection and tumor occurrence.  When these mechanisms are ineffective or somehow bypassed, tumors or chronic infections may form. Clarifying the processes leading to ineffective immune defense is the central goal of the
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Antibody Engineering and Therapeutics conference

The Antibody Engineering and Therapeutics conference will take place December 11th-15th 2017 at the Manchester Grand Hyatt in San Diego, California.
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Mustafa Diken speaks at Future Medicine 2017.

The Berlin Institute of Health, together with the Charité Universitätsmedizin Berlin, Max Delbrück Center for Molecule Medicine and Tagesspiegel, will host the second Future Medicine: Innovation in Health Science meeting on 7th November.
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