TRON Seminar in Translational Oncology
September 3, 2015
“Immunosurveillance of the liver by intravascular effector CD8+ T cells”
Matteo Iannacone, MD, PhD
San Raffaele Scientific Institute, Milan, Italy
5 PM, Lecture Hall Building 708, University Medical Center Mainz
Langenbeckstr. 1, 55131 Mainz, Germany
The Iannacone research laboratory seeks to dissect the complex dynamics of host-virus interactions with a particular focus on the development and function of adaptive immune responses. To simulate the complex interplay of physical, cellular, biochemical, and other factors that influence cell behavior in microvessels and interstitial tissues, Dr. Iannacone’s lab makes use of intravital microspcopy. This technique is complemented by more traditional molecular, cellular and histological approaches, thus characterizing host-virus interactions at the molecular-, single cell- and whole animal-level.
In his research Dr. Iannacone wants to:
- characterize how viruses are handled within draining lymph-nodes upon peripheral inoculation and how antiviral immune responses are generated
- dissect the pathogenetic mechanisms underlying liver immunopathology during viral hepatitis
- discover and characterize novel adjuvants for adaptive immune responses
Dr. Iannacone is a group leader in the Division of Immunology and Director of the Intravital Imaging Facility at the San Raffaele Scientific Institute in Milan. Previously he was a Postdoctoral Fellow at the Laboratory of Prof. L.G. Guidotti and Prof. F.V. Chisari at the Scripps Research Institute, La Jolla, and a Senior Research Associate at the Laboratory of Prof. Ulrich von Andrian at the Harvard Medical School in Boston, US.
Please find additional information about Dr. Iannacone and his lab at: http://www.iannaconelab.com/
Information about his publications can be found at: http://www.ncbi.nlm.nih.gov/pubmed/?term=Iannacone+M[Author]