December 3, 2014
“New preclinical test system for an improved analysis of monoclonal antibody function”
11:30 AM in Mainz, Germany
Lecture Hall, Building 706, at University Medical Center Mainz
Prof. Dr. Ulrich Kalinke
Prof. Kalinke is Executive Director of TWINCORE, Centre for Experimental and Clinical Infection Research. TWINCORE is a joint venture between the Medical University Hanover and the Helmholtz Center for Infection Research, Germany. TWINCORE is a translational center, closely linking basic and clinical research focused on the search for new strategies to improve diagnosis, prevention and treatment of human infectious diseases. The multidisciplinary research teams integrate clinical and basic research to channel knowledge arising from basic research into clinical practice, and also to translate clinical observations into an improved understanding of disease mechanisms.
Specializing in virus infection induced innate immunity, Dr. Kalinke worked as a Staff Scientist and Leader of the “Anti-Viral Defense Group” at the European Molecular Biology Laboratory (EMBL) in Italy. He was Director and Professor of the Division of Immunology at the Paul-Ehrlich-Institute in Langen, Germany, where he was responsible for all licensing aspects of monoclonal and polyclonal antibodies and of therapeutic vaccines. At the PEI, he also addressed regulatory research issues such as challenges and opportunities of biosimilar monoclonal antibodies and new developments in therapeutic tumor vaccines. At his current position he is developing a translational infection research program at TWINCORE. In addition to undertaking basic and translational research projects he is involved in the development of new teaching formats to distribute knowledge about regulatory issues relevant for clinical trial applications, e.g. scientific basis for risk assessment in advance of clinical trials. In his own group he is currently studying anti- viral immunity and viral immune evasion. Another focus is the analysis of virus control within the central nervous system.
Keywords: Type I interferon, antiviral immune response, mouse models, primary human immune cells, biomarkers, therapeutic monoclonal Antibodies, vaccines, adjuvants, formulations