In a new research paper in the September issue of OncoImmunology, TRON scientists determined the HLA type and HLA expression of 167 cancer and 10 non-cancer cell lines.
Using standard NGS RNA-Seq short reads from “whole transcriptome” sequencing and mapping reads to known HLA types, the study by TRON documents previously unreported HLA class I and II genotypes and their expression. The results are a fundamental resource for all researchers selecting cancer cell lines based on the HLA type and HLA expression, as well as for the development of immunotherapeutic tools for cancer immunotherapies.
Boegel, S., Loewer, M., Bukur, T., Sahin, U., Castle, J.C. A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines. OncoImmunology. 11 Sep. 2014.