Mainz, Germany, April 18, 2018 – Ugur Sahin, Scientific Director at TRON, has been awarded one of the prestigious ERC Advanced Grants 2017 for his project ‘SUMMIT – Stepping Up mRNA Mutanome Immunotherapy’, totaling 2.5 Million Euros over 5 years. The ERC Advanced Grants are awarded to well-established, leading principal investigators to pursue ground-breaking projects. SUMMIT is one
Insight into the human HLA expression pattern opens up new ways of improving cancer vaccine development The human leukocyte antigen system (HLA system) is a group of genes that are central to the function of the immune system. These protein complexes can be found either on almost all cells (HLA class I complex) or on
Mainz, March 23, 2018 – TRON is delighted to announce a review authored by Ugur Sahin and Özlem Türeci in the journal Science. “Personalized vaccines for cancer immunotherapy” outlines the genetic basis for why almost every cancer is unique, and how with innovations in mutation mapping, target validation and vaccine production, it is possible to
Mainz, March 16, 2018 – The Dutch Society for Immunology (NVVI) is hosting the 4th Chemical Immunology Conference today in Amsterdam. The meeting aims to cover the broad diversity of chemical immunology and some of the most exciting areas of research to have emerged. TRON’s Mustafa Diken kicks off the day with his plenary, “mRNA
Mainz, March 2018 – On March 15th, Prof. Dietmar Zehn from the Technical University of Munich, School of Life Sciences Weihenstephan, will be visiting Mainz in the context of our Seminars in Translational Oncology series (SITO). You are cordially invited to his talk at 5 pm in building 708 of the University Medicine Mainz. The
Mainz, February 16, 2018 – The Keystone Symposium on Antibodies as Drugs: Translating Molecules into Treatments, will take place February 25th – March 1st, 2018 at the Whistler Conference Centre in Whistler, Canada. Ugur Sahin will speak in the session on Novel Ways to Deliver Antibody Therapy on Thursday, March 1. The title of his lecture
We are pleased to announce a three-year grant from the Falconwood Foundation, New York, USA, totalling 3 Million Euros. The grant supports the launch of a new research project to identify biomarkers specific for neuroendocrine tumors (NETs) that are crucial for the development of new, personalized immunotherapies to treat NET patients. Further details are announced
TRON has been shortlisted for Cancer Research UK’s Grand Challenge Award as part of team BLUEPRINT TRON is part of a multi-disciplinary team of scientists that has been shortlisted to the final stages of Cancer Research UK’s Grand Challenge*. The team is led by Dr. Lindy Durrant from the University of Nottingham and includes
Mainz, January 29, 2018 – The K. G. Jebsen Center for Cancer Immunotherapy is holding a mini-symposium on The Next Generation of Cancer Immunotherapy. In this context, on February 2 Prof. Ugur Sahin will give a lecture on Personalized Mutanome Vaccines.
Mainz, January 23, 2018 – The Keystone Symposium on Lymphocytes and their Role in Cancer will take place February 11th-15th 2018 at the Keystone Resort in Keystone, Colorado. This is a joint event with Emerging Cellular Therapies: T Cells and Beyond. Ugur Sahin will chair the session on Cellular Therapies in Blood Malignancies, and give a
The concept of delivering genetic material to defective cells to treat diseases or to vaccinate healthy people against infections has been around for quite some time. Nevertheless, key challenges remain, such as efficient delivery of the material as well as duration of gene expression.
In the course of evolution, the immune system has developed sophisticated mechanisms to identify and eliminate invading pathogens and degenerate cells, thereby preventing infection and tumor occurrence. When these mechanisms are ineffective or somehow bypassed, tumors or chronic infections may form. Clarifying the processes leading to ineffective immune defense is the central goal of the